PERIACTINE 4MG 30 tablets

PERIACTINE 4MG 30 tablets

This medication is an antiallergic antihistamine . It also has atropinic and sedative properties.

It is used in the treatment of various allergic manifestations: allergic rhinitis or conjunctivitis, hives, conjunctivitis.

Directions for use and dosage

Oral use.
RESERVED FOR ADULTS AND CHILDREN OVER 6 YEARS.

• Adult : 1 to 5 tablets maximum per day. In general, 3 tablets to distribute during the day.
• Child over 6 years : 2 to 3 tablets to be divided into two to three doses per day.

It is advisable to privilege the evening doses because of the sedative effect of cyproheptadine.

Comment on the advice for use and dosage of PERIACTINE 4MG 30 tablets with our partner Avis checked after your purchase.

Composition

The active substance is :
Cyproheptadine. 4.00 mg
(In the form of hydrochloride). 4.34 mg

For one tablet

The other ingredients are : calcium hydrogen phosphate dihydrate, lactose monohydrate, pregelatinized corn starch, potato starch, magnesium stearate.

Precautions for use

In case of renal or hepatic insufficiency, CONSULT YOUR DOCTOR so that he can adjust the dosage.
Taking this medication requires medical advice in the elderly:

• predisposed to constipation, orthostatic hypotension (low blood pressure when standing), dizziness or drowsiness;
• with abnormalities of the prostate;

And in case of gastroduodenal anomaly (stomach ulcer, duodenum). TELL YOUR DOCTOR before taking this antihistamine.
Alcoholic beverages or drugs containing alcohol during the course of treatment are not recommended due to the risk of increased sedative effect.

IF IN DOUBT, DON'T HESITATE TO ASK YOUR DOCTOR OR PHARMACIST FOR ADVICE.

Taking or using other medications:
If you are taking or have recently taken any other medicines, including medicines obtained without a prescription, tell your doctor or pharmacist.

This medication contains an antihistamine, cyproheptadine. Other drugs contain it. Do not combine them, so as not to exceed the maximum recommended dose.

The cyproheptadine in this medicine may cause a false positive reaction to tests for tricyclic antidepressants (for example in the urine and blood);

Pregnancy
The use of this medication is not recommended during pregnancy.
If you discover that you are pregnant during treatment, consult your doctor quickly: only he can adapt the treatment to your condition.

Feeding with milk
In the absence of data on passage into breast milk, taking this medication is not recommended during breast-feeding.
Ask your doctor or pharmacist.

Driving and using machines
Attention is drawn, in particular to drivers of vehicles and users of machines, to the risks of drowsiness attached to the use of this drug, especially at the start of treatment.
this phenomenon is accentuated by taking alcoholic beverages or drugs containing alcohol.

Presentation of PERIACTINE 4MG 30 tablets

Box of 30 tablets

Our advice and opinions from pharmacy experts

• The time to reach a maximum plasma concentration of cyproheptadine after oral administration is 6 to 9 hours. The elimination half-life is between 10 and 15 hours. Metabolism consists of demethylation followed by oxidation and hydroxylation, then sulfoconjugation. Elimination via the kidneys accounts for 2/3 to 3/4 of the total clearance. About 5% of the amount of cyproheptadine administered is found in unchanged form in the urine.
• Pathophysiological variation : elimination is reduced in patients with renal insufficiency, there is a risk of overdose in these patients.

Pharmacovigilance Report an adverse drug reaction(s)

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Hypo-allergenic

cyproheptadine

. Presentations . Composition . Indications . Contraindications . Attention . Drug interactions . Pregnancy and breastfeeding . Instructions for use and dosage . Side effects . Lexicon

PRESENTATIONS ^(summary)

PERIACTIN: tablet (white); box of 30.
Not refunded - Free price -

Laboratory Teofarma SRL

COMPOSITION ^(summary)

	p cp
cyproheptadine	4 mg
Lactose	+

INDICATIONS ^(summary)

This medicine is an antiallergic antihistamine . It also has atropinic and sedative properties .
It is used in the treatment of various allergic manifestations: allergic rhinitis or conjunctivitis , urticaria .

CONTRAINDICATIONS ^(summary)

This medicine should not be used in the following cases:

• antecedent agranulocytosis ,
  
• risk of blockage of urine ( adenoma of the prostate ...),
  
• risk of narrow angle glaucoma ,
  
• child under 6 years old (risk of mis-driving with tablets).
  

ATTENTION ^(summary)

This medicine has atropinic effects. It can cause acute glaucoma in predisposed people: red eye, hard and painful, with blurred vision. An emergency consultation with an ophthalmologist is necessary.
Taking this medicine exposes you to a very rare but serious risk: agranulocytosis . It can be manifested by a high fever, angina. One of these events requires stopping treatment and blood tests: tell your doctor urgently.
Because of the sedative and atropine properties of this antihistamine , precautions are necessary in patients with renal insufficiency and in the elderly, especially in cases of chronic constipation, prostate adenoma , tendency to vertigo or dizziness .
Avoid alcoholic beverages: increased risk of drowsiness.
This medicine can induce drowsiness, sometimes severe in some people. This drowsiness may be increased by taking alcohol or other sedative medications. Driving and using dangerous machines is not recommended, especially within hours of taking the medication.

DRUG INTERACTIONS ^(summary)

Tell your doctor or pharmacist if you are taking any other medicine that has atropine or sedative effects (tranquilizers, sleeping pills, some cough or pain medicines containing opiates , antidepressants , neuroleptics ...).

PREGNANCY and BREASTFEEDING ^(summary)

The effect of this medicine during pregnancy or breastfeeding is poorly understood. As a precaution, its use is not recommended for pregnant women or breastfeeding women.

DIRECTIONS AND DOSAGE ^(summary)

The tablets should be swallowed with a little water, during or outside meals. Favor the catch of the evening because of the risk of drowsiness.

Usual dosage:

• Adult: 1 to 5 tablets a day.
  
• Child from 6 to 15 years old: 1 tablet, 2 or 3 times a day.
  

ADVERSE POSSIBLE EFFECTS ^(summary)

Drowsiness.
Atropine effects: dryness of the mouth, disturbances of accommodation , blockage of urine, constipation, palpitations .
Orthostatic hypotension , vertigo , tremors, agitation.
Allergic reaction .
Anomaly of the blood count .
Excitement, nervousness, agitation, hallucinations, mental confusion, lowering of concentration.
Jaundice, increased transaminases .
Increased appetite, weight gain.

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LEXICON ^(summary)

accommodation
"Focus" of the eye, allowing close-up vision. Presbyopia is the most common accommodation disorder; certain medications such as atropine can cause transient accommodation disturbances.


prostate adenoma
Increase in the volume of the prostate gland located under the bladder of the man. This increase in volume is benign, has nothing to do with cancer, but may hinder the passage of urine in the canal (urethra) that passes through the gland.
The symptoms that suggest the presence of a prostate adenoma are:

• Difficulty urinating (slow, weak jet)
  
• the need to get up several times a night to urinate;
  
• urges to urinate imperious and difficult to control.
  

Some drugs, especially atropine, may have the undesirable effect of aggravating the discomfort and may lead to a complete blockage of the evacuation of the bladder. They are therefore contraindicated or should be used with caution in men with the symptoms described above.


agranulocytosis
Disappearance of white blood cells. This serious condition prevents the body from reacting to infections. It is most often due to the toxicity of a drug on the bone marrow, where blood cells are made.


alcohol
General name for a family of substances that have the property of being able to be mixed with water and fat. The most common alcohol is ethyl alcohol (ethanol), but there are many other alcohols: methanol, butanol, etc. The degree of an alcoholic solution corresponds to the volume of pure alcohol present in 100 ml of solution, knowing that 1 glass of wine flask or 1 half of beer (25 cl) contain about 8 g of alcohol.
When alcohol is used as an antiseptic, a denaturant with an unpleasant smell is often added to prevent it from being drunk. Contrary to popular belief, alcohol at 70o (or even at 60o) is a better antiseptic than alcohol at 90o.


antecedent
Affection healed or still evolving. The antecedent can be personal or family. The antecedents are the story of a person's health.


antidepressants
Drug that acts against depression. Some antidepressants are also used to combat obsessive-compulsive disorder, generalized anxiety, some rebel pain, enuresis, etc.
Depending on their mode of action and their adverse effects, antidepressants are divided into different families: imipramine antidepressants, serotonin reuptake inhibitors, MAOIs (selective or non-selective). Finally, other antidepressants do not belong to any of these families because they possess original properties.
The mode of action of antidepressants has two main aspects: the relief of the moral suffering and the fight against the inhibition which removes any will of action to the depressed. Sometimes there is a discrepancy between these two effects: the moral suffering can persist, while the capacity for action reappears. During this short period, the suicidal risk present in some depressed may be increased. The doctor takes this into account when prescribing (possible association with a tranquilizer) and this must be respected.


antihistamine
Drug that opposes the different effects of histamine. Two main types exist: antihistamines type H1 (antiallergic) and antihistamines type H2 (gastric antiulcer). Some H1 antihistamines are sedative, others do not affect alertness.


atropine
Drug whose effects are close to those of atropine. Atropinics fight spasms and diarrhea. The adverse effects of atropinic agents are: thickening of bronchial secretions, dryness of the mouth and mucous membranes, constipation, risk of blockage of urine and acute glaucoma attack in susceptible persons, disturbances of accommodation, abnormal sensitivity to light by dilation of the pupil. Taking several atropine drugs increases the risk of side effects. In case of overdose or accidental ingestion, the following signs may also appear: red and hot skin, fever, acceleration of breathing, drop or, on the contrary, rise in blood pressure, agitation, hallucinations, poor coordination of movements. Tell your doctor urgently or, if not, call 15, 112 or an emergency medical service.
In addition to atropine and its derivatives, other drugs have atropine effects: imipramine antidepressants, some antihistamines, antispasmodics, antiparkinsonian and neuroleptics.


conjunctivitis
Inflammation of the conjunctiva due to a foreign body, an allergy, an infection or an irritant.


glaucoma
Disease characterized by the increase of the pressure of the liquids contained in the eye (intraocular hypertension).
This general term covers two completely different affections:

• Open-angle glaucoma or chronic glaucoma is the most common; it is usually symptom free, detected by measurement of intraocular pressure in the ophthalmologist. It does not cause an acute attack, and the treatment is essentially based on beta-blocker eye drops. People with open-angle glaucoma should not use cortisone derivatives without prior ophthalmic advice.
  
• Angle-closure glaucoma or acute glaucoma is more rare. Between seizures, intraocular tension is normal. But the inadvertent use of atropine drugs (especially eye drops) causes an acute attack of intraocular hypertension that can permanently damage the retina in a few hours. It is an ophthalmological emergency that can be recognized by a brutally red eye, horribly painful, hard as a glass ball, and whose vision becomes blurred.
  

The angle referred to in these two affections is the iridocorneal angle. It is indeed between the iris and the cornea that the liquid evacuation system of the eye is located. A slightly open angle (closed) exposes to a total obstruction of the evacuation system. This obstruction can occur when the iris is open to the maximum (mydriasis) under the effect of an atropine drug: the iris then sticks to the cornea.
The contraindications for atropine medications only apply to people who have had an angle-closure glaucoma attack, or for whom an ophthalmologist has detected this risk. Those with chronic open angle glaucoma are not affected by these contraindications.


Orthostatic hypotension
Decreased blood pressure when moving from lying to standing. Mostly due to medications, orthostatic hypotension results in dizziness with risk of falling, especially in the elderly. These disorders can be prevented by avoiding abrupt changes of position: sit for a few moments on the edge of the bed before standing up, slowly get up from a seat while keeping a support before moving.
The wearing of compression stockings, which prevents blood from flowing back to the legs while standing, is also used to treat orthostatic hypotension.


insufficient renal
Inability of the kidneys to dispose of waste or drugs. Advanced renal failure does not necessarily result in a decrease in the amount of urine eliminated. Only a blood test and the determination of creatinine can reveal this disease.


neuroleptics
Family of drugs used in the treatment of certain nervous disorders or various symptoms: digestive disorders, menopausal disorders, etc.


blood count
The count measures the number of red blood cells (red blood cells), white blood cells (leucocytes) and platelets in the blood. The blood formula specifies the percentage of different white blood cells: neutrophils, eosinophils, basophils, lymphocytes, monocytes.
Abbreviation: NFS.


opiates
Chemical family that includes opium and its derivatives. In addition to drugs such as opium or heroin, the opiate family includes morphine (strong analgesic), codeine (antitussive and analgesic) and many other substances.


palpitations
Abnormal perception of irregular heartbeat.


Allergic reaction
Reaction due to the hypersensitivity of the body to a drug. Allergic reactions can be very varied: urticaria, angioedema, eczema, rash of measles-like pimples, etc. Anaphylactic shock is a generalized allergic reaction that causes discomfort by sudden drop in blood pressure.


rhinitis
Inflammation or infection of the nose and nasal cavity. Rhinitis can have an infectious origin (bacterium or virus) or an allergic origin. Allergic rhinitis includes seasonal rhinitis (hay fever) and rhinitis called perennial, that is to say, often persistent during the year (for example due to dust mites, animal hair or chemical agents) .


sedative

• Soothing, calm.
  
• Medicines belonging to different families: anxiolytics, hypnotics, analgesics, antitussives, antiepileptics, neuroleptics, etc. but also antidepressants, antihistamines H1, antihypertensives. A sedative may be responsible for drowsiness and increase the effects of alcohol.
  

transaminases
Enzymes dosed in the blood, the rate of which rises during certain hepatitis. They appear in blood tests under the name of SGOT and SGPT or ASAT and ALAT.


urticaria
Rash of pimples on the skin, the origin of which is most often allergic. The pimples look like stinging nettles and vary in color from pale pink to red.


dizziness
Symptom that may indicate a sense of loss of balance (common sense) or, more strictly, a feeling of rotation on oneself or the environment (medical sense).