NAUTAMINE prevention and treatment of motion sickness 20 tablets

NAUTAMINE prevention and treatment of motion sickness 20 tablets

For warnings, precautions and contraindications, please consult the Nautamine package insert.

Description of Nautamine

Nautamine tablets are indicated for adults and children over 2 years of age for the prevention and treatment of motion sickness.

Motion sickness gives rise to a variety of symptoms, the intensity of which varies from person to person.
Initially, the symptoms may be :

• a feeling of discomfort in the upper abdomen (a frequent sign) ;
• nausea;
• in young children, disgust with food, crying, restlessness and/or yawning.

Other symptoms may include

• paleness ;
• cold sweats ;
• hypersalivation
• vomiting;
• dizziness ;
• rapid breathing ;
• headaches;
• fatigue.

Composition

Di(aceflylline) diphenhydramine: 90 mg per tablet.

Excipients : Colloidal silica hydrate, potato starch, magnesium stearate, indigotine (E132), microcrystalline cellulose, ethylcellulose.

Nautamine drug dosage

For adults and children over 2 years of age.

Children aged 2 to 6: crush 1/4 or 1/2 tablet and pour into a glass of water. 1/2 crushed tablet per dose, to be taken 1/2 hour before departure. Repeat if necessary after 6 hours, without exceeding 4 crushed half-tablets per day.

Children aged 6 to 12: Tablets should be swallowed with a glass of water. 1 tablet to be taken 1/2 hour before departure. Repeat if necessary after 6 hours, without exceeding 4 tablets per day.

Adults and children over 12: Tablets should be swallowed with a glass of water. 1 to 1.5 tablets to be taken 1/2 hour before departure. Repeat if necessary after 6 hours, without exceeding 6 tablets per day.

Precautions for use

• Nautamine should not be used if you are breast-feeding.
• This non-prescription medication should not be used in the event of treatment with enoxacin.
• In the event of long-term liver or kidney disease, consult your doctor so that he/she can adjust the dosage.
• Elderly people predisposed to constipation, dizziness or drowsiness, or with prostate disorders, should seek medical advice before taking this medicine.
• This drug may cause drowsiness which may be aggravated by alcohol: abstain from alcoholic beverages or drugs containing alcohol during treatment.
• Nautamine contains the antihistamine diphenydramine. Other drugs contain diphenydramine. Do not combine them, so as not to exceed the maximum recommended dose.
• It is possible to take this medicine during pregnancy, provided you take it for a short time (a few days) and at the recommended dose. Indeed, at the end of pregnancy, excessive use of this drug may have harmful effects on the newborn. Therefore, always seek your doctor's advice before using it.
• This non-prescription drug passes into breast milk. It is therefore not recommended for nursing mothers.
• Store at a temperature not exceeding 30°C.
• Do not exceed expiration date.

Contraindications

• Children under 2 years of age due to pharmaceutical form,
• Certain forms of glaucoma (increased pressure inside the eye),
• Difficulty urinating due to prostatic or other causes,
• Known allergy to antihistamines,
• If breast-feeding,
• In case of treatment with enoxacin.

Read instructions before use.

Route of administration : Oral

Packaging

Box of 20 coated tablets

Drug warnings

Nautamine is not a product like any other. Read the Nautamine package insert carefully before ordering. Keep medicines out of the reach of children. If symptoms persist, ask your doctor or pharmacist for advice. Beware of incompatibilities with your current products.

• Please inform your online pharmacist of your current treatments to identify any incompatibilities. The order validation form contains a personalized message field for this purpose.
• Click here to find the package leaflet for this drug on the Agence Nationale de Sécurité du Médicament et des Produits de Santé website.

Advice

How to prevent motion sickness?
There are a number of preventive measures you can take to ease the pain of motion sickness:

• Eat lightly before you leave - not much food, but you must eat to avoid an empty stomach.
• Avoid alcohol, tobacco and coffee before and during the journey. Avoid fatty and/or spicy foods during transport.
• Look at a fixed point on the horizon, far ahead, and do not look at books, maps, video screens (films, games) or waves through windows.
• Don't wear tight-fitting clothes to avoid compressing your stomach.
• Take a small blanket, as the cold aggravates symptoms.

Pharmacovigilance Report an adverse drug reaction(s)

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antiemetic

diphenhydramine

. Presentations . Composition . Indications . Contraindications . Warning . Drug Interactions . Pregnancy and breastfeeding . Directions for use and dosage . Advice . Undesirable effects . Lexicon

PRESENTATIONS ^(summary)

NAUTAMINE: scored tablet (blue); box of 20.
-

Laboratory Sanofi-Aventis France

COMPOSITION ^(summary)

	p cp
Diphenhydramine di-acefylline	90 mg

INDICATIONS ^(summary)

This medication belongs to the family of H1 type antihistamines . It also has sedative and atropine effects which explain certain precautions of use.
It is used to prevent and treat motion sickness.

CONTRAINDICATIONS ^(summary)

This medication should not be used in the following cases:

• risk of closed-angle glaucoma ,
  
• risk of urine retention,
  
• child under 2 years of age.
  

WARNING ^(Contents)

Precautions are necessary in patients with severe hepatic impairment or renal insufficiency and in the elderly, especially in cases of chronic constipation, prostate adenoma , tendency to dizziness or drops in tension.
Avoid alcoholic beverages: increased risk of drowsiness.
This medication may induce somnolence, sometimes intense in some people. This drowsiness can be increased by taking alcohol or other sedative drugs. Driving and using hazardous machines are not recommended, especially within hours of taking the medication.

DRUG INTERACTIONS ^(summary)

Tell your doctor or pharmacist if you are taking any other medicines that have atropine or sedative effects (tranquillizers, sleeping pills, some cough or pain medications containing opioids , antidepressants , neuroleptics, etc.).

PREGNANCY AND BREAST-FEEDING ^(summary)

Pregnancy :
Use of this medication during pregnancy is possible, provided that the recommended dosage is followed. However, its use in the days prior to delivery should be reported to the physician; in fact, special surveillance of the newborn may be necessary.

Breastfeeding:
This drug passes into breast milk; do not use or reuse without medical advice.

DIRECTIONS FOR USE AND DOSAGE ^(summary)

This medication should be taken with a little water, half an hour before departure. The catch may be renewed during the trip, within 6 hours.
For children under 6, tablets should be crushed before being swallowed.

Usual dosage:

• Adult and child over 12 years: 1 tablet or 1 and a half tablets, to be renewed if necessary, without exceeding 6 tablets per day.
  
• Child 6 to 12 years: 1 tablet, to be renewed if necessary, without exceeding 4 tablets per day.
  
• Child 2 to 6 years: ½ tablet, to be renewed if necessary, without exceeding 4 half-tablets per day.
  

TIPS ^(summary)

There are simple and often effective measures to prevent motion sickness:

• sleep well on the eve of the trip;
  
• eat lightly but regularly during the ride;
  
• avoid coffee, alcoholic or soft drinks;
  
• privilege certain places: in front by coach, at the level of the wings by plane, on the bridge in the center by boat.
  

POSSIBLE ADVERSE EFFECTS ^(summary)

Drowsiness.
Atropine effects: dry mouth, difficulty in accommodation , blocked urine, constipation, palpitations .
Orthostatic hypotension , dizziness , tremors, restlessness.
Allergic reaction .
Abnormal blood count .
Drowsiness.
Atropine effects: dry mouth, difficulty in accommodation , blocked urine, constipation, palpitations .
Orthostatic hypotension .
Dizziness , impaired balance, decreased concentration, usually in the elderly.
Tremors, confusion of ideas, hallucinations; more rarely, restlessness, nervousness, insomnia.
Allergic reaction .
Abnormal blood count .
Cases of abuse, misuse and dependency have been observed, especially among adolescents.

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GLOSSARY ^(summary)

accommodation
"Focus" of the eye, allowing clear vision close up. Presbyopia is the most common disorder of accommodation; some drugs such as atropine may cause passenger accommodation problems.


adenoma of the prostate
Increase in the volume of the prostate gland located under the bladder of the man. This increase in volume is benign, has no relationship to cancer, but can interfere with the passage of urine into the urethra through the gland.
Symptoms that suggest the presence of a prostate adenoma are:

• difficulty urinating (slowness, weakness of the spray);
  
• the need to get up several times at night to urinate;
  
• urges to urinate imperiously and difficult to control.
  

Certain drugs, especially atropinic drugs, may have the undesirable effect of aggravating the discomfort and may lead to a total blockage of the evacuation of the bladder. They are therefore contraindicated or should be used cautiously in men with the symptoms described above.


alcohol
General name designating a family of substances that have the property of being able to be mixed with water and fatty substances. The most common alcohol is ethyl alcohol (ethanol), but there are many other alcohols: methanol, butanol, etc. The degree of alcoholic solution corresponds to the volume of pure alcohol present in 100 ml of solution, knowing that 1 glass of wine or 1/2 of beer (25 cl) contains about 8 g of alcohol.
When alcohol is used as an antiseptic, an unpleasant odor denaturant is often added to prevent drinking. Contrary to a widespread belief, alcohol at 70o (or even at 60o) is a better antiseptic than alcohol at 90o.


antidepressants
Medication that works against depression. Some antidepressants are also used to combat obsessive-compulsive disorder, generalized anxiety, certain rebellious pain, enuresis, etc.
Depending on their mode of action and adverse effects, antidepressants are divided into different families: imipraminic antidepressants, serotonin reuptake inhibitors, selective or non-selective MAOIs. Finally, other antidepressants do not belong to any of these families, because they possess original properties.
The mode of action of antidepressants has two main aspects: the relief of moral suffering and the fight against inhibition which removes all will to action from the depressed. There may be a time lag between these two effects: moral suffering may persist, while the capacity for action reappears. During this short period, the risk of suicide in some depressed people can be increased. The physician takes it into account in its prescription (possible association with a tranquillizer) and it must imperatively be respected.


antihistamines
Medication that opposes different effects of histamine. Two main types exist: antihistamines type H1 (antiallergic) and antihistamines type H2 (gastric antiulcer). Some antihistamines of type H1 are sedative, others do not alter vigilance.


atropine
Medication with effects similar to those of atropine. Atropinics fight spasms and diarrhea. Adverse effects of atropinic drugs include: thickening of bronchial secretions, dry mouth and mucous membranes, constipation, risk of urine blockage and acute glaucoma in susceptible persons, accommodation disorders, abnormal sensitivity to light by dilation of the pupil. Taking several atropine medicines increases the risk of adverse effects. In the event of overdose or accidental ingestion, the following signs may also appear: red and warm skin, fever, acceleration of breathing, fall or, on the contrary, elevated blood pressure, agitation, hallucinations, poor coordination of movements. Emergency care should be given to your doctor or, if not available, call 15, 112 or an emergency medical service.
In addition to atropine and its derivatives, other drugs have atropine effects: imipraminic antidepressants, some antihistamines, antispasmodics, antiparkinsonian and neuroleptic.


addiction
Psychic or physical need caused by taking certain natural or medicinal substances. This condition may be accompanied, at cessation of the catch, by various symptoms, grouped under the term of withdrawal syndrome.


glaucoma
Disease characterized by increased pressure of the fluids contained in the eye (intraocular hypertension).
This general term covers two totally different affections:

• Open angle glaucoma or chronic glaucoma is the most frequent; it is generally symptom-free, detected by the measurement of intraocular tension in the ophthalmologist. It does not cause acute seizures, and treatment relies primarily on beta-blocking eye drops. People with open-angle glaucoma should not use cortisone derivatives without prior ophthalmologic advice.
  
• Closed-angle glaucoma or acute glaucoma is more rare. Between seizures, intraocular tension is normal. But the inadvertent use of atropine medicines (especially eye drops) causes an acute crisis of intraocular hypertension which can permanently damage the retina in a few hours. It is an ophthalmological emergency that is recognized by a brutally red eye, horribly painful, hard as a glass ball, and whose vision becomes blurred.
  

The angle in question in these two affections is the irido-corneal angle. It is indeed between the iris and the cornea that is located the system of evacuation of the liquids of the eye. A slightly open (closed) angle exposes a total obstruction of the evacuation system. This obstruction can occur when the iris is opened to the maximum (mydriasis) under the effect of an atropinic drug: the iris then comes to be attached to the cornea.
Contraindications for atropine medicines are limited to those who have already had closed-angle glaucoma or who have been detected by an ophthalmologist. Those who suffer from chronic open-angle glaucoma are not affected by these contraindications.


Orthostatic hypotension
Reduced blood pressure when changing from elongated to standing. Due mostly to drugs, orthostatic hypotension results in dizziness with risk of fall, especially in the elderly. These disturbances can be prevented by avoiding sudden changes of position: sit for a few moments at the edge of the bed before standing up, slowly rising from a seat with a support before moving.
Wearing compression stockings, which prevents blood from flowing back to the legs while standing, is also used to treat orthostatic hypotension.


Hepatic insufficiency
Inability of the liver to perform its function, which is essentially the elimination of some waste, but also the synthesis of many biological substances essential to the body: albumin, cholesterol and coagulation factors (vitamin K, etc.).


renal failure
Inability of the kidneys to eliminate waste or medicinal substances. Advanced renal insufficiency does not necessarily result in a decrease in the amount of urine excreted. Only a blood test and creatinine dosage may reveal this disease.


neuroleptics
Family of medicines used in the treatment of certain nervous disorders or various symptoms: digestive disorders, menopausal disorders, etc.


new born
Child less than one month old.


blood count
The count measures the number of red blood cells (red blood cells), white blood cells (leukocytes) and platelets in the blood. The blood formula specifies the percentage of different white blood cells: neutrophils, eosinophils, basophils, lymphocytes, monocytes.
Abbreviation: NFS.


opiates
A chemical family that includes opium and its derivatives. In addition to drugs such as opium or heroin, the opiate family includes morphine (strong analgesic), codeine (antitussive and analgesic) and many other substances.


palpitations
Abnormal perception of irregular heartbeat.


dosage
Quantity and distribution of the dose of a drug according to the age, weight and general condition of the patient.


Allergic reaction
Reaction due to hypersensitivity of the organism to a drug. Allergic reactions can take a wide variety of aspects: urticaria, angioedema, eczema, eruption of pimples resembling measles, etc. Anaphylactic shock is a generalized allergic reaction that causes discomfort due to a sudden drop in blood pressure.


sedatives

• Quiets, calms down.
  
• Medication belonging to different families: anxiolytics, hypnotics, analgesics, cough suppressants, antiepileptics, neuroleptics, etc. but also antidepressants, antihistamines H1, antihypertensives. A sedative can be responsible for drowsiness and increase the effects of alcohol.
  

dizziness
Symptom that can mean an impression of loss of balance (common sense) or, more strictly, a sense of rotation on oneself or the environment (medical sense).