Over-the-counter medication

RHINADVIL Cold Stuffy nose 20 tablets

Name: RHINADVIL Cold Stuffy nose 20 tablets
Brand: GlaxoSmithKline
SKU: 2925
Price: 4.99 EUR
Availability: InStock
Rating: 4.4286 (7 reviews)

Brand : GlaxoSmithKline

€4.54 EXCL. VAT €4.99 INCL. VAT

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Reference : 3400933408480

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RhinAdvil Hay is a medicine that contains a non-steroidal anti-inflammatory with analgesic properties, ibuprofen and a vasoconstrictor, hydrochloride pseudoéphérine. RhinAdvil Hay is indicated during colds adolescents (15-17 years) and adults for symptomatic treatment sensations stuffy nose accompanied by headache and / or fever.

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Presentation - How to use - Composition

RHINADVIL Cold stuffy nose 20 tablets

For warnings, precautions for use and contraindications, please consult the instructions for use.

The common cold is the most common and recurrent virus, especially in the city. By breathing microbes, viruses and other allergens, the mucous membrane swells. We then end up with lots of phlegm in the runny nose, which congestion and this can last for a week, if you are lucky that the cold does not turn into sinusitis or bronchitis.
To protect yourself from colds, some hygiene measures are necessary :

Wash your hands regularly and teach your children to do the same;
Avoid sharing glasses, forks, spoons… of the infected person;
Minimize contact with sick people;
Do not put your hands on your face and cover your mouth when you sneeze;
Use disposable tissues so that you do not re-contaminate yourself.

Description Rhinadvil Cold

RhinAdvil Cold is a medicine that contains a nonsteroidal anti-inflammatory drug, with analgesic properties, ibuprofen and a vasoconstrictor, pseudoepherine hydrochloride. RhinAdvil Cold is indicated, during colds in adolescents (15-17 years) and adults, for the symptomatic treatment of stuffy nose sensations accompanied by headaches and / or fever .

Reserved for adults and children over 15 years old.

Composition Rhinadvil Cold

Ibuprofen 200mg, pseudoephedrine hydrochloride 30mg
Excipients : corn starch, pregelatinized potato starch, croscarmellose.

Dosage

1 tablet per dose, to be renewed if necessary after 6 hours, without exceeding 6 tablets per day.

Take preferably during the meal.

Contraindications

In children and adolescents under 15 years of age
From 6th month of pregnancy (on prescription only during the first two trimesters of pregnancy)
Patients with a history of allergy or asthma triggered by taking this or a related drug, including other nonsteroidal anti-inflammatory drugs, aspirin or if you have a history of allergy to others constituents of the tablet
Patients with a history of gastrointestinal bleeding or perforation, related to previous treatment with NSAIDs or a history of recurrent peptic ulcer or hemorrhage
Severe liver disease, severe kidney disease, severe heart failure, high blood pressure, gastrointestinal bleeding or other red blood cell abnormalities, stroke
Severe heart disease, certain forms of glaucoma, difficulty urinating, old or recent seizures, history of myocardial infarction, systemic lupus erythematosus,
If you are breastfeeding
If you are being treated with other vascoconstrictor medicines, or non-selective MAOI medicines
In combination with: oral anticoagulants, platelet aggregation inhibitors, other non-steroidal anti-inflammatory drugs, corticosteroids, heparin injectable in curative doses, lithium, selective serotonin reuptake inhibitors, methotrexate

Route of administration : oral

Read the instructions carefully

Conditioning

Box of 20 tablets

What is the official price of this non-prescription drug? No official price in pharmacies, the price is freely set for each pharmacist.
Summary of product characteristics (ANSM)

Warnings on drugs purchased online

Please note, the drug Rhinadvil Cold is not a product like the others. Read the package leaflet carefully before ordering. Keep medicines out of the reach of children. If symptoms persist, seek the advice of your doctor or pharmacist. Beware of incompatibilities on your current products.

Please inform your online pharmacist of the treatments in progress in order to identify any incompatibilities. The order validation form contains a personalized message field provided for this purpose.
Click here to find the leaflet for this medication on the website of the National Agency for the Safety of Medicines and Health Products.

Notice

Pharmacovigilance Report an adverse drug reaction(s)

Download PDF leaflet

NOTICE

ANSM - Updated on: 30/07/2015

Name of the medicinal product

RHINADVIL RHEUME IBUPROFENE / PSEUDOEPHEDRINE, coated tablet

Ibuprofen / pseudoephedrine hydrochloride

framed

Read this leaflet carefully before you start taking this medicine. It contains important information for your treatment and illness.

If you have any further questions, ask your doctor or pharmacist.

· Keep this leaflet, you may need to read it again.

· If you need more information and advice, ask your pharmacist.

· If symptoms worsen or persist, consult a physician.

· If you notice any side effects not listed in this leaflet, or if you experience any of the effects listed as serious, please tell your doctor or pharmacist.

Review summary

In this notice :

1. WHAT IS RHINADVIL RHUME IBUPROFENE / PSEUDOEPHEDRINE, coated tablet AND WHAT CASES IS IT USED FOR?

2. BEFORE YOU TAKE RHINADVIL RHUME IBUPROFENE / PSEUDOEPHEDRINE, coated tablet?

3. HOW TO TAKE RHINADVIL RHUME IBUPROFENE / PSEUDOEPHEDRINE, coated tablet?

4. WHAT ARE POSSIBLE SIDE EFFECTS?

5. HOW TO STORE RHINADVIL RHUME IBUPROFENE / PSEUDOEPHEDRINE, coated tablet?

6. ADDITIONAL INFORMATION

1. WHAT IS RHINADVIL RHUME IBUPROFENE / PSEUDOEPHEDRINE, coated tablet AND WHAT CASES IS IT USED FOR?

Pharmacotherapeutic group

This medicine contains a non-steroidal anti-inflammatory drug, with analgesic and antipyretic properties, ibuprofen and a vasoconstrictor, pseudoephedrine hydrochloride.

Therapeutic indications

Adolescent (15-17 years) and adult colds are indicated for symptomatic treatment of stuffy nose sensations accompanied by headache and / or fever.

2. BEFORE YOU TAKE RHINADVIL RHUME IBUPROFENE / PSEUDOEPHEDRINE, coated tablet?

List of information needed before taking the medication

Not applicable.

Cons-indications

Do not take RHINADVIL RHUME IBUPROFENE / PSEUDOEPHEDRINE, coated tablet:

Child and adolescent less than 15 years old.

· From 6 ^th month of pregnancy.

· Patients with a history of allergy or asthma triggered by the use of this drug or a related drug, including other non-steroidal anti-inflammatory drugs, aspirin or a history of allergy to others components of the tablet.

· Patients with a history of gastrointestinal bleeding or perforation associated with prior NSAID therapy or a history of recurrent peptic ulcer or hemorrhage.

· Severe liver disease.

· Serious kidney disease.

· Severe heart failure.

· severe or poorly balanced arterial hypertension.

· Gastrointestinal bleeding or other abnormal red blood cells.

· If you have had a stroke.

· Severe heart disease (coronary insufficiency).

· certain forms of glaucoma (increased pressure in the eye).

· difficulty urinating from prostatic or other causes.

· convulsions.

· history of myocardial infarction.

· systemic lupus erythematosus.

· If you are treated by:

o other vasoconstrictive medicinal products intended for decongesting the nose whether they are administered orally or nasally (phenylpropanolamine, phenylephrine, ephedrine, etc.) or methylphenidate,

o non-selective MAOI drugs (iproniazide), medicines prescribed in some depressive states.

· If you are breastfeeding.

You should not use this medication unless your doctor has advised otherwise:

· until the ^5th month of pregnancy

· in association with:

o oral anticoagulants,

o antiplatelet agents,

o other non-steroidal anti-inflammatory drugs (including aspirin and other high-dose salicylates),

o corticosteroids,

o heparin injectable at curative doses or in the elderly,

o lithium,

o selective serotonin reuptake inhibitors,

o methotrexate (used at doses greater than 20 * mg per week).

Precautions for use; special warnings

Take special care with RHINADVIL RHUME IBUPROFENE / PSEUDOEPHEDRINE, coated tablet:

At high doses, greater than 6 tablets per day (1200 mg / day of ibuprofen and 180 mg / day of pseudoephedrine), this drug has anti-inflammatory properties and can cause serious discomforts, which are observed with anti-inflammatory drugs - inflammatory.

DO NOT LEAVE THIS MEDICINE OR SCOPE OR CHILDHOOD.

In case of overdosage or mistakenly taking too high a dose, immediately notify a doctor.

It is imperative to strictly observe the dosage, the duration of treatment of 5 days, and the contraindications.

Drugs such as RHINADVIL RHUME IBUPROFENE / PSEUDOEPHEDRINE may be associated with a slight increase in the risk of heart attack (myocardial infarction) or stroke; the risk is more likely with high doses and long-term treatment; do not exceed the dose or duration of treatment (5 days).

If you have heart problems, have had a stroke, or if you think you may have a risk (eg, high blood pressure, diabetes, high cholesterol, or to take this treatment you should talk to your doctor or pharmacist.

BEFORE YOU USE THIS MEDICINE, CONSULT YOUR DOCTOR IN CASE:

· A history of asthma associated with chronic rhinitis, chronic sinusitis or polyps in the nose; the administration of this specialty may lead to an asthma attack, especially in some people who are allergic to aspirin or to a non-steroidal anti-inflammatory drug ( see section 2, Information required before taking RHINADVIL RHUME IBUPROFENE / PSEUDOEPHEDRINE ... );

· Taking anticoagulant therapy. This medication may cause severe gastrointestinal symptoms;

· A history of gastrointestinal problems (hiatus hernia, digestive hemorrhage, old stomach or duodenal ulcer);

· Diseases of the heart, liver, kidney;

· Hypertension;

· Cardiac disorders, hyperthyroidism (hyperfunction of the thyroid gland);

· Personality or diabetes disorders;

· When taking medicines to treat migraine (especially alkaloid drugs derived from rye ergot);

· When taking the following medicines: ciclosporin, tacrolimus, trimethoprim.

DURING TREATMENT, IN CASE OF:

· Eye disorders, PREVENT YOUR DOCTOR;

· Feeling of acceleration of heartbeat, palpitations, onset or increase of headache, nausea, behavioral disturbances;

· Gastrointestinal haemorrhage (discharge from the mouth or stool, stool coloration in black);

· Possible side effects with RHINADVIL RHUME IBUPROFENE / PSEUDOEPHEDRINE, coated tablet? ). Allergic reactions such as asthma or angioedema ( see section 4 "Possible side effects with RHINADVIL RHUME IBUPROFENE / PSEUDOEPHEDRINE, coated tablet" ).

STOP TREATMENT AND CONTACT IMMEDIATELY MEDICAL OR EMERGENCY MEDICAL SERVICE

Because of the presence of sucrose, this medication should not be used in cases of fructose intolerance, glucose-galactose malabsorption syndrome or sucrase-isomaltase deficiency (rare metabolic diseases.

Due to the presence of methyl and propyl parahydroxybenzoates (preservatives), possible allergic reactions or even delayed allergy reaction may occur.

In case:

Purulent nasal discharge

Persistence of fever

Lack of improvement after 5 days of treatment

CONSULT YOUR DOCTOR

If you have to undergo anesthesia, stop the treatment and notify the anesthesiologist.

This drug contains a non-steroidal anti-inflammatory drug, ibuprofen and a vasoconstrictor, pseudoephedrine hydrochloride.

You should not take other medicines containing non-steroidal anti-inflammatory drugs and / or aspirin and / or pseudoephedrine together with this medication.

Read carefully the leaflets for other medicines you are taking to ensure that there are no non-steroidal anti-inflammatory drugs and / or aspirin and / or pseudoephedrine.

Interaction with other medicines

Taking or using other medicines

Please tell your doctor or pharmacist if you are taking or have recently taken any other medicines, including:

· antiplatelet agents and oral anticoagulants,

· other non-steroidal anti-inflammatory drugs including aspirin and its derivatives at high doses,

· corticosteroids,

· of the injectable heparin,

· lithium,

· selective serotonin reuptake inhibitors,

· of high-dose methotrexate (greater than 20 * mg per week),

· ticlopidine,

· ciclosporin, tacrolimus, trimethoprim,

· medicines for the treatment of high blood pressure,
Even if it is a non-prescription drug.

In addition, this medicinal product contains a vasoconstrictor, pseudoephedrine hydrochloride, which should NOT be mixed:

· to other vasoconstrictive drugs intended for decongesting the nose whether they are administered orally or nasally (phenylpropanolamine, phenylephrine, ephedrine, etc.) and to methylphenidate,

· medications prescribed in certain depressive states: non-selective MAOIs (iproniazide).

It is also not recommended to combine this medication:

· to selective MAO-A,

· to linezolid,

· dopaminergic or vasoconstrictive ergot alkaloids such as bromocriptine, pergolide, lisuride, cabergoline, ergotamine, dihydroergotamine.

If in doubt, do not hesitate to seek the advice of your doctor or pharmacist

Interactions with food and beverages

Not applicable.

Interactions with Herbal Medicines or Alternative Therapies

Not applicable.

Use during pregnancy and lactation

Pregnancy and breast feeding

Pregnancy

If you are pregnant or breastfeeding: Do not take this medicine without consulting your doctor or pharmacist.

Use of this medicine is not recommended until the ^5th month of pregnancy and included is against-indicated from the ^6th month of pregnancy.

Ask your doctor or pharmacist for advice before taking any medicine.

feeding

Due to possible adverse effects in infants, taking this medication is contraindicated if you are breast-feeding.

Ask your doctor or pharmacist for advice before taking any medicine.

Sport

Sport

Pseudoephedrine hydrochloride may induce a positive reaction from tests performed during doping controls.

Effects on ability to drive or use machines

Driving and using machines

In rare cases, taking this medicine may cause dizziness and blurred vision.

List of excipients with known effect

List of excipients with a known effect: sucrose, methyl parahydroxybenzoates and propyl.

3. HOW TO TAKE RHINADVIL RHUME IBUPROFENE / PSEUDOEPHEDRINE, coated tablet?

Instructions for proper use

Not applicable.

Dosage, Mode and / or route (s) of administration, Frequency of administration and Duration of treatment

Dosage

RESERVED TO ADOLESCENT (15-17 years) AND THE ADULT

1 tablet (200 mg ibuprofen / 30 mg pseudoephedrine hydrochloride) per dose, to be renewed if necessary after 6 hours.

In case of more severe symptoms, 2 tablets (400 mg ibuprofen / 60 mg pseudoephedrine hydrochloride) per dose, to be renewed if necessary after 6 hours, without exceeding 6 tablets (1200 mg ibuprofen / 180 mg pseudoephedrine hydrochloride) per day.

In all cases, never exceed the maximum dose of 6 tablets per day (1200 mg ibuprofen and 180 mg pseudoephedrine hydrochloride per day).

Administration mode

Oral use.

The tablets should be swallowed as they are with a large glass of water, preferably during meals.

Frequency of Administration

Catches must be spaced at least 6 hours apart.

If you feel that the effect of RHINADVIL RHUME IBUPROFENE / PSEUDOEPHEDRINE, coated tablet, does not work as you expected: consult your doctor or pharmacist.

Duration of treatment

The maximum duration of treatment is 5 days.

Symptoms and Instructions for Overdose

If you take more RHINADVIL RHEUME IBUPROFENE / PSEUDOEPHEDRINE, coated tablet than you should:

Take the advice of your doctor.

Instructions for omission of one or more doses

If you forget to take RHINADVIL RHUME IBUPROFENE / PSEUDOEPHEDRINE, coated tablet:

Do not take a double dose to make up for a missed dose.

Risk of withdrawal syndrome

If you stop taking RHINADVIL RHUME IBUPROFENE / PSEUDOEPHEDRINE, coated tablet:

If you have any further questions on the use of this medication, ask your doctor or pharmacist.

4. WHAT ARE POSSIBLE SIDE EFFECTS?

Description of adverse reactions

Like all medicines, RHINADVIL RHUME IBUPROFENE / PSEUDOEPHEDRINE, coated tablet is likely to have side effects, although not everyone is subject to it.

Some drugs, such as RHINADVIL RHUME IBUPROFENE / PSEUDOEPHEDRINE may be associated with a slight increase in the risk of myocardial infarction or stroke.

Tell your doctor or pharmacist if you experience any gastrointestinal disturbances (such as pain or heartburn) at the start of treatment, or if you have experienced problems with previous anti-inflammatory treatments, especially if you are an elderly person.

Stop your treatment immediately if you notice any skin, mucous membrane (eg inside the mouth) or signs of allergy.

RHINADVIL RHUME IBUPROFENE / PSEUDOEPHEDRINE, coated tablet may cause the following side effects:

· Sensation of acceleration of heartbeat, palpitations, onset or increase of headache, nausea, behavioral disorders (linked to the presence of pseudoephedrine hydrochloride).

· Gastrointestinal haemorrhage (discharge from the mouth or in the stool, stool coloration in black) in rare cases; this is all the more frequent because the dosage used is high (linked to the presence of ibuprofen).

· Signs suggestive of allergy to this medication include asthma attack, angioedema (abrupt swelling of the face and neck with respiratory discomfort) or skin allergies (rash on the skin, itching, swelling, aggravation of urticaria chronic, erythema).

· Bullous manifestations of the skin or mucous membranes, (burning sensations accompanied by redness with bubbles, blisters, ulcerations).

IN THESE CASES, STOP THE TREATMENT AND CONTACT IMMEDIATELY A DOCTOR OR AN EMERGENCY MEDICAL SERVICE.

In addition, during treatment, the following effects may occur:

· Digestive disorders: stomach upset, vomiting, nausea, diarrhea, constipation;

· The possibility of triggering an acute glaucoma crisis in predisposed subjects;

· Urinary disorders (significant decrease urine difficulty urinating) especially in cases of abnormal urethra, prostate, renal failure;

· Dryness of the mouth, palpitations;

· Convulsions, hallucinations, agitation, anxiety, insomnia, especially in children.

You should tell your doctor.

Exceptionally, may occur:

· Headache accompanied by nausea, vomiting and stiff neck;

· Changes in liver function or blood count (reduction in white blood cells or red blood cells) may be severe;

· Difficulty in sight;

· Hemorrhagic strokes have been reported in patients treated with medicinal products containing pseudoephedrine, in particular in the case of non-compliance with contraindications or warnings ( see section 2 "INFORMATION REQUIRED BEFORE TAKING RHINADVIL RHUME IBUPROFENE / PSEUDOEPHEDRINE , coated tablet " ).

If you notice any side effects not listed in this leaflet, or if any of the side effects gets serious, contact your doctor or pharmacist.

5. HOW TO STORE RHINADVIL RHUME IBUPROFENE / PSEUDOEPHEDRINE, coated tablet?

Keep out of the reach and sight of children.

Expiration date

Do not use after the expiry date stated on the carton.

The expiry date refers to the last day of the month.

Storage conditions

Store at a temperature not exceeding + 25 ° C.

If necessary, warnings against visible signs of deterioration

Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist what to do with unused medications. These measures will help protect the environment.

6. ADDITIONAL INFORMATION

Full list of active substances and excipients

What does RHINADVIL RHUME IBUPROFENE / PSEUDOEPHEDRINE contain in a coated tablet?

The active substances are :

Ibuprofen ................................................. .................................................. ................................ 200.00 mg

Pseudoephedrine hydrochloride ............................................... .................................................. .. 30.00 mg

For a coated tablet.

The other components are :

Corn starch, pregelatinized potato starch, croscarmellose sodium, anhydrous colloidal silica, sodium laurilsulfate, stearic acid.

Coating: sucrose, microcrystalline cellulose, OPAGLOS GS-2-0310 (shellac, povidone K30) Opalux AS-3739 (titanium dioxide (E171), yellow iron oxide (E172), red iron oxide (E172), sucrose , povidone K30, methyl parahydroxybenzoate (E218), propyl parahydroxybenzoate (E216)), black ink (OPACODE S-1-17823), carnauba wax.

Pharmaceutical form and content

What is RHINADVIL RHUME IBUPROFENE / PSEUDOEPHEDRINE, coated tablet and contents of the pack?

This medication is in the form of a coated tablet, oval, brown-pink, printed RHINADVIL on one side. Box of 20.

Name and address of the marketing authorization holder and the holder of the manufacturing authorization responsible for the release of the lots, if different

Holder

PFIZER FAMILY HEALTH

23-25, AVENUE OF DOCTOR LANNELONGUE

75014 PARIS

exploiting

PFIZER FAMILY HEALTH

23-25 rue du Docteur Lannelongue

75014 PARIS

Maker

WYETH SpA

VIA NETTUNENSE, 90

04011 APRILIA

ITALY

Names of the medicinal product in the Member States of the European Economic Area

This medicinal product is authorized in the Member States of the European Economic Area under the following names:

In accordance with the regulations.

Date of approval of the notice

The last date on which this leaflet was approved is {date}.

AMM under exceptional circumstances

Not applicable.

Internet Information

Detailed information on this medicine is available on the Ansm website (France).

Information for health professionals only

Not applicable.

Other

Not applicable.

Vidal file

VIDAL OF THE FAMILY

RHINADVIL

Anti-rheumatic medication

ibuprofen, pseudoephedrine

. Presentations . Composition . Indications . Contraindications . Warning . Drug Interactions . Pregnancy and breastfeeding . Directions for use and dosage . Advice . Undesirable effects . Lexicon

PRESENTATIONS ^(summary)

RHINADVIL: tablet (red); box of 20.
-

Pfizer Family Health Laboratory

COMPOSITION ^(summary)

	p cp
Ibuprofen	200 mg
Pseudoephedrine hydrochloride	30 mg
Sucrose	+

INDICATIONS ^(summary)

This medication contains ibuprofen, a nonsteroidal anti-inflammatory drug ( NSAID ) that has an analgesic and antipyretic action, and pseudoephedrine, a decongestant vasoconstrictor that reduces the sensation of blocked nose.
It is used to relieve symptoms of colds: stuffy nose, runny nose, headache and / or fever.

CONTRAINDICATIONS ^(summary)

This medication should not be used in the following cases:

history of allergy or asthma induced by aspirin or nonsteroidal anti - inflammatory drugs ( NSAIDs );
ulcer of the stomach or duodenum ;
severe hepatic insufficiency ;
severe renal failure ;
severe heart failure ;
systemic lupus erythematosus ;
arterial hypertension not controlled by specific treatment;
severe coronary artery disease;
history of stroke ;
history of seizures ;
risk of closed angle glaucoma ;
risk of blocking urine ( adenoma of the prostate );
in combination with an anti - depressant of the non-selective MAOI type or for at least 15 days after taking it;
in combination with another decongestant vasoconstrictor or a vasoconstrictor containing one of the following substances: bromocriptine, pergolide, lisuride, cabergoline, ergotamine or dihydroergotamine;
child under 15 years of age;
pregnancy (from the 6th month);
breastfeeding .

WARNING ^(Contents)

Prolonged treatment or overdosage of NSAIDs may result in serious adverse reactions.
Although it is available without a prescription, it contains a vasoconstrictor that can cause potentially serious cardiac or neurological adverse effects. Its use requires certain precautions, including compliance with doses and contraindications. Make sure you do not associate it with another medication containing a decongestant vasoconstrictor , especially nasally.
Decongestant vasoconstrictors can increase heart rate ( tachycardia ) and cause palpitations and nausea. If these adverse effects are too severe, treatment should be discontinued.
They may also be responsible for rare neurological complications ( convulsions , hallucinations, abnormal agitation), in particular in the case of excessive dosage . Respect the recommended dose.
It is recommended to take medical advice in the event of high blood pressure , heart disease, hyperthyroidism , diabetes , nervous disorders, history of stomach ulcer or duodenum or risk of bleeding, especially digestive ( Crohn 's disease , ulcerative colitis ).
Some situations should lead to further treatment only after medical advice:

severe heartburn or black and foul-smelling stools that may indicate irritation or bleeding of the digestive tract;
rash without obvious cause;
asthma attack ;
unusual and intense fatigue, or a sharp and significant decrease in the volume of urine in a person suffering from heart failure , dehydration or diuretic treatment.

Taking this medicine may cause acute glaucoma in susceptible persons: red, hard and painful eye, with blurred vision. An emergency consultation with an ophthalmologist is necessary.
NSAIDs have an inhibitory effect on ovulation and are likely to decrease fertility in women. This effect is reversible upon discontinuation of treatment.
Some doctors consider that anti-inflammatories can decrease the effectiveness of intrauterine devices (IUDs) and expose them to an unwanted pregnancy risk. This risk is highly controversial.
Conductor: This medication may be responsible, in rare cases, for dizziness or disturbances of vision.
Sports: This medicinal product contains a substance considered as stimulant (phenylephrine, pseudoephedrine or synephrine), which is included in the 2004 monitoring program of the Ministry of Youth and Sports. It can be found in athletes' urine to detect any misuse.

DRUG INTERACTIONS ^(summary)

This medication should not be combined with:

an antidepressant of the non-selective MAOI type ( MARSILID ): a period of at least 15 days must be respected between the taking of these 2 medicines;
another vasoconstrictor orally (phenylephrine, pseudoephedrine, methylphenidate) or a vasoconstrictor nasally (naphazoline, oxymetazoline, ephedrine sulfate or tuaminoheptane): risk of hypertensive crisis.

It may interact with vasoconstrictors used in Parkinson's disease (bromocriptine, pergolide, lisuride, cabergoline) or in migraine (ergotamine, dihydroergotamine, methysergide) or with selective AIMM (moclobemide).
It may also interact with other drugs, including aspirin, other non- steroidal anti-inflammatory drugs, anticoagulants , antiplatelet agents, and drugs containing lithium or methotrexate.
Also tell your doctor or pharmacist if you are taking an antihypertensive medication, diuretic or medicine containing guanethidine.

PREGNANCY AND BREAST-FEEDING ^(summary)

Pregnancy :
Adverse effects to the unborn child have been demonstrated when NSAIDs are used during the last 4 months of pregnancy; the risk exists even with a single intake and even if the pregnancy is over term. The use of this medication is contraindicated during this period.
During the first 5 months, the effect of this medication is poorly understood: only your doctor can evaluate the possible risk of its use in your case.

Breastfeeding:
This drug passes into breast milk. It is contraindicated during breast-feeding.

DIRECTIONS FOR USE AND DOSAGE ^(summary)

The tablets are swallowed with a glass of water, preferably during meals.

Usual dosage:

Adult and children over 15 years: 1 or 2 tablets per dose to be renewed if necessary every 6 hours, not to exceed 6 tablets per day.

The duration of treatment should not exceed 5 days.

TIPS ^(summary)

This medicine has no anti-infectious effect. If the condition persists for more than a few days, consult your doctor.

POSSIBLE ADVERSE EFFECTS ^(summary)

Related to ibuprofen:
Nausea, vomiting, gastritis .
Rarely:

stomach or duodenal ulcer , haemorrhage of the digestive tract (bloody vomiting, black stools, or mostly imperceptible blood loss, responsible for the progressive onset of anemia ) most often during long-term treatment duration or high dose;
allergic reaction : rash , itching, edema , asthma attack , malaise with sudden drop in blood pressure;
dizziness , headache;
vision disorders requiring ophthalmological examination;
abnormal blood count , increased transaminases .

Related to pseudoephedrine:
Dry mouth, urinary retention.
Nausea, vomiting.
Palpitations , acceleration of the heart, insomnia, anxiety, headaches, sweating.
More rarely: hallucinations, agitation.

GLOSSARY ^(summary)

stroke
Brain injury due to haemorrhage or abrupt obstruction of an artery. Depending on the size of the lesion, the consequences are more or less serious: temporary discomfort, paralysis, coma.
Abbreviation: AVC.

adenoma of the prostate
Increase in the volume of the prostate gland located under the bladder of man. This increase in volume is benign, has no relationship to cancer, but can interfere with the passage of urine into the urethra through the gland.
Symptoms that suggest the presence of a prostate adenoma are:

difficulty urinating (slowness, weakness of the spray);
the need to get up several times at night to urinate;
urges to urinate imperiously and difficult to control.

Some drugs, especially atropinics, may have the undesirable effect of aggravating the discomfort and may lead to a total blockage of the bladder evacuation. They are therefore contraindicated or should be used cautiously in men with the symptoms described above.

NSAIDs
Abbreviation for non-steroidal anti-inflammatory drug. Family of anti-inflammatory drugs that are not derived from cortisone (steroids), and the best known of which is aspirin.

allergy
Skin reaction (itching, pimples, swelling) or general discomfort occurring after contact with a particular substance, use of a medication, or ingestion of food. The main forms of allergy are eczema, urticaria, asthma, angioedema and allergic shock (anaphylactic shock). Food allergy can also result in digestive disorders.

anemia
Reduction in the level of hemoglobin in the blood, which usually results in a decrease in the number of red blood cells. Iron is essential for the synthesis of hemoglobin. Iron deficiency during pregnancy, a vegetarian diet, abundant or repeated haemorrhage (menstruation) is a common cause of anemia. Other causes, more rare, are related to vitamin deficiencies of group B.

analgesic
Medication that works against pain. Analgesics act either directly on the centers of pain in the brain or by blocking the transmission of pain to the brain.
Synonym: analgesic.

antecedent
Affection healed or always in evolution. The antecedent may be personal or family. The background is the history of a person's health.

antiplatelet agents
Medication that prevents the platelets from clumping and therefore the clots from forming. The oldest platelet antiaggregant is aspirin taken in small doses.
Anti-aggregants should not be confused with anticoagulants with a different mechanism of action.

anti coagulants
Medication that prevents blood from coagulating and therefore prevents clots from forming in the blood vessels.
Anticoagulants are used to treat or prevent phlebitis, pulmonary embolism, certain infarcts. They also prevent the formation of clots in the heart during rhythm disorders such as atrial fibrillation or in the case of an artificial heart valve.
There are two main types of anticoagulants:

oral anticoagulants, which block the action of vitamin K (antivitamin K, or AVK) and whose effectiveness is controlled by a blood test: INR (formerly TP);

injectable anticoagulants derived from heparin, the efficacy of which can be controlled by the blood assay of anti-Xa activity, Howell's Time (TH) or Cephalin Kaolin Time (TCK) depending on the products used. A regular dosage of blood platelets is necessary throughout the life of a heparin derivative.

antidepressant
Medication that works against depression. Some antidepressants are also used to combat obsessive-compulsive disorder, generalized anxiety, certain rebellious pain, enuresis, etc.
Depending on their mode of action and adverse effects, antidepressants are divided into different families: imipraminic antidepressants, serotonin reuptake inhibitors, selective or non-selective MAOIs. Finally, other antidepressants do not belong to any of these families, because they possess original properties.
The mode of action of antidepressants has two main aspects: the relief of moral suffering and the fight against inhibition which removes all will to action from the depressed. There may be a time lag between these two effects: moral suffering may persist, while the capacity for action reappears. During this short period, the risk of suicide in some depressed people can be increased. The physician takes it into account in its prescription (possible association with a tranquillizer) and it must imperatively be respected.

antihypertensive
Medication that fights against excess blood pressure. The main ones are beta-blockers, diuretics, calcium channel blockers, ACE inhibitors, angiotensin II inhibitors and vasodilators.

anti-inflammatory
Medicine that fights against inflammation. It can be either derived from cortisone (steroidal anti-inflammatory), or not derived from cortisone (nonsteroidal anti-inflammatory or NSAID).

antipyretic
Medication used to lower the body temperature during bouts of fever.

asthma
Disease characterized by difficulty breathing, often resulting in wheezing. Asthma, permanent or occurring by crisis, is due to a narrowing and inflammation of the bronchi.

convulsions
Involuntary contractions limited to a few muscles or generalized to the whole body. They are due to excessive pain or stimulation of the brain: fever, poisoning, lack of oxygen, brain damage. Convulsions may be due to an epileptic seizure or high fever in young children.

Crohn
inflammation of the intestine, which can cause ulcers and narrowing. It often becomes chronic and can be accompanied by persistent diarrhea and malnutrition.

diabetes
A general term for diseases that result in the emission of abundant urine and intense thirst. The word diabetes, used alone, is generally related to diabetes mellitus, which corresponds to a disruption in the regulation of the body's sugars by insulin. It results in increased sugar (glucose) in the blood and its possible presence in the urine. There are two types of diabetes mellitus: Type 1 or insulin-dependent diabetes, which requires insulin injections, and type 2 or non-insulin dependent diabetes, which can initially be treated with oral antidiabetics.

diuretic
Medication allowing increased kidney water removal. Most often, this loss of water follows the loss of salts caused by the drug (salidiuretic).
Diuretics are mainly used in the treatment of high blood pressure, while their mechanism of action in this disease is poorly understood. They are also prescribed in acute or chronic heart failure, edema and other rarer ailments.
These drugs cause loss of sodium and potassium (except for some of them called "potassium-sparing"). Their prolonged administration therefore requires regular blood potassium control, to avoid heart problems that may result from hypokalemia (lack of potassium in the blood). Lack of sodium is another possible but less frequent consequence of the prolonged use of diuretics; it is also detected by a blood test.

duodenum
A part of the intestine into which food from the stomach penetrates.

skin rash
Appearance of pimples or plaques on the skin. These lesions can be due to a food, a drug, and translate an allergy or a toxic effect. Many viruses can also cause pimple eruptions: rubella, roseola and measles are the most common.

gastritis
Inflammation of the stomach favored by stress, tobacco, alcohol and certain drugs such as aspirin or anti-inflammatory drugs.

glaucoma
Disease characterized by increased pressure of the fluids contained in the eye (intraocular hypertension).
This general term covers two totally different affections:

Open angle glaucoma or chronic glaucoma is the most common; it is generally symptom-free, detected by the measurement of intraocular tension in the ophthalmologist. It does not cause acute seizures, and treatment relies primarily on beta-blocking eye drops. People with open-angle glaucoma should not use cortisone derivatives without prior ophthalmologic advice.
Closed-angle glaucoma or acute glaucoma is more rare. Between seizures, intraocular tension is normal. But the inadvertent use of atropine medicines (especially eye drops) causes an acute crisis of intraocular hypertension which can permanently damage the retina in a few hours. It is an ophthalmological emergency that is recognized by a brutally red eye, horribly painful, hard as a glass ball, and whose vision becomes blurred.

The angle in question in these two affections is the irido-corneal angle. It is indeed between the iris and the cornea that is located the system of evacuation of the liquids of the eye. A slightly open (closed) angle exposes a total obstruction of the evacuation system. This obstruction can occur when the iris is opened to the maximum (mydriasis) under the effect of an atropinic drug: the iris then comes to be attached to the cornea.
Contraindications for atropine medicines are limited to those who have already had closed-angle glaucoma or have been detected by an ophthalmologist. Those who suffer from chronic open angle glaucoma are not affected by these contraindications.

hemorrhage
Loss of blood from an artery or vein. Hemorrhage can be external, but also internal and go unnoticed.

high blood pressure
Excess blood pressure (tension) in the arteries. This pressure is provided by the heart and is expressed by two digits. It is maximal during contraction of the heart, or systole (first digit), and minimal during cardiac rest, or diastole (second digit). High blood pressure is characterized by a maximum (systolic) pressure greater than or equal to 16, or a minimum (diastolic) pressure greater than or equal to 9.5. Treatment is initiated when these numbers are exceeded or for lower blood pressure in some people with cardiovascular risk factors: heredity, smoking, diabetes, excess cholesterol. Permanent antihypertensive therapy reduces damage to the heart and blood vessels due to high blood pressure.

hyperthyroidism
Excessive thyroid hormones, including heart failure, poor heat tolerance, weight loss and chronic fatigue.

MAOIs
Abbreviation for mono-amine oxidase inhibitor. Family of drugs used in psychiatry and neurology (depression, Parkinson's disease). These drugs are divided into non-selective MAOIs, which are incompatible with many drugs and even certain foods, and selective MAOIs (A or B), for which these disadvantages are absent or limited.

heart failure
Inability of the heart to fulfill its function as a pump. The main symptoms of heart failure are fatigue and shortness of breath during an effort.

coronary heart disease
Partial disability of the arteries of the heart (coronary arteries) to irrigate the heart muscle. Seizures of angina pectoris can occur, most often during an effort.

Hepatic insufficiency
Inability of the liver to perform its function, which is essentially the elimination of some waste, but also the synthesis of many biological substances essential to the body: albumin, cholesterol and coagulation factors (vitamin K, etc.).

renal failure
Inability of the kidneys to eliminate waste or medicinal substances. Advanced renal insufficiency does not necessarily result in a decrease in the amount of urine excreted. Only a blood test and creatinine dosage may reveal this disease.

lupus erythematosus
Skin disease causing redness of the central part of the face. There are two main forms: discoid lupus (only cutaneous) and disseminated lupus (associated with lesions of the deep organs).

blood count
The count measures the number of red blood cells (red blood cells), white blood cells (leukocytes) and platelets in the blood. The blood formula specifies the percentage of different white blood cells: neutrophils, eosinophils, basophils, lymphocytes, monocytes.
Abbreviation: NFS.

edema
Accumulation of water or lymph causing localized swelling.

palpitations
Abnormal perception of irregular heartbeat.

Parkinson
Chronic disease of the nervous system related to the alteration of certain brain cells and resulting in mobility disorders and sometimes tremors.

dosage
Quantity and distribution of the dose of a drug according to the age, weight and general condition of the patient.

allergic reaction
Reaction due to hypersensitivity of the organism to a drug. Allergic reactions can take a wide variety of aspects: urticaria, angioedema, eczema, eruption of pimples resembling measles, etc. Anaphylactic shock is a generalized allergic reaction that causes discomfort due to a sudden drop in blood pressure.

ulcerative colitis
Inflammatory disease of the rectum and colon, which evolves by flare-ups. Each flare is accompanied by fever, bloody stools.

overdose
Taking an excessive amount of a drug exposes you to an increase in the intensity of adverse effects, or even to the appearance of particular adverse effects.
This overdose may result from accidental or voluntary poisoning for suicide, so consult your local Poison Control Center (listed in the appendix to the book). However, in most cases, overdose is the result of an error in the understanding of the prescription, or the search for an increase in efficacy by exceeding the recommended dosage. Finally, untimely self-medication may lead to excessive absorption of the same substance contained in different drugs. Some drugs are particularly prone to this risk because they are (wrongly) considered to be harmless: vitamins A and D, aspirin, etc. Stopping or decreasing drug intake helps to remove the disorders associated with an overdose.

tachycardia
Accelerating the rhythm of the heartbeat. It may be due to fever, hyperthyroidism, heart disease, certain medications, and so on.

transaminases
Enzymes dosed in the blood, which rate rises during some hepatitis. They are included in blood tests as SGOT and SGPT or ASAT and ALAT.

ulcer
Injury of skin, mucous membranes or cornea.

Leg ulcer: chronic wound due to poor circulation of blood.
Gastroduodenal ulcer: a localized wound in the mucosa of the stomach or duodenum due to excess acidity and very often to the presence of a bacterium (Helicobacter pylori). The ulcer is favored by stress, alcohol, smoking and certain medications (aspirin, NSAIDs, etc.).

vasoconstrictor
Medication that causes contraction of blood vessels, as opposed to vasodilator.

dizziness
Symptom that can mean an impression of loss of balance (common sense) or, more strictly, a sense of rotation on oneself or the environment (medical sense).

Pharmacist's advice

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