What is Milbetel Dog Deworming Tablet used for?
Milbemycin oxime belongs to the macrocyclic lactone group, produced by fermentation of Streptomyces hygroscopicus var. aureolacrimosus. It is active against mites, the larval and adult stages of nematodes and the larvae of Dirofilaria immitis.
Milbemycin's activity is linked to its action on neurotransmission in invertebrates: in nematodes and insects, milbemycin oxime, like avermectins and other milbemycins, increases membrane permeability to chloride ions via glutamate-dependent chloride channels (related to GABAA and glycine receptors in vertebrates). This leads to hyperpolarization of the neuromuscular membrane, resulting in flaccid paralysis and death of the parasite.
Praziquantel is an acetylated derivative of pyrazino-isoquinoline. Praziquantel is active against cestodes and trematodes. It alters membrane permeability to calcium (Ca2+ influx) in the parasite, causing an imbalance in membrane structures and leading to membrane depolarization, almost instantaneous muscle contractions (cramps) and rapid vacuolization of the integumentary syncytium, responsible for integument decomposition (blistering). This facilitates elimination in the gastrointestinal tract or leads to the death of the parasite.
Biocanina Laboratories'Milbetel Chien is a multi-purpose, broad-spectrum dewormer for dogs weighing over 5kg. It is designed to treat mixed infestations by immature and adult stages of the following cestodes (flatworms) and nematodes (roundworms):
- Cestodes (flatworms) : Dipylidium caninum, Taenia spp, Echinococcus multilocularis
- Nematodes (roundworms) : Ancylostoma tubaeforme, Toxocara cati
Thanks to its innovative formula, Milbetel Chiens is also used for the prevention of heartworm disease (Dirofilaria immitis), if concomitant treatment against cestodes is indicated.
Biocanina veterinary laboratory also offers Milbetel dewormer for small dogs and puppies, at the best price in our online pharmacy.
How to use this dewormer
Oral administration. Minimum recommended dose: 0.5 mg milbemycin oxime and 5 mg praziquantel per kg bodyweight, administered as a single oral dose.
The product should be administered during or after meals.
The tablets are meat-flavored and easy to administer (dogs and puppies usually take them voluntarily, even without food).
Milbetel Dog Vermifuge should be administered during or after meals, to provide optimum protection against heartworm disease. Depending on the dog's weight, the dose to be administered is as follows:
- Dogs from 5 to 25kg: 1 tablet
- Dogs from 25 to 50kg: 2 tablets
- Dogs from 50 to 75kg: 3 tablets
Do not use dog tablets for dogs weighing less than 5kg.
For treatment of Angiostrongylus vasorum infestations, administer milbemycin oxime 4 times at one-week intervals. When concomitant treatment against cestodes is indicated, it is recommended to administer the product once and then continue treatment for the remaining three weeks with a monovalent product containing milbemycin oxime.
In endemic areas, if concomitant treatment against cestodes is indicated, administration of the product every 4 weeks helps prevent angiostrongylosis by reducing the parasite load in immature adults (L5) and adults.
For the treatment of infestations by Thelazia callipaeda, milbemycin oxime should be administered in two treatments separated by 7 days. If concomitant treatment against cestodes is indicated, the drug can replace the monovalent product containing milbemycin oxime alone.
What are the precautions for use?
Do not use in dogs weighing less than 5 kg.
Do not use in the event of hypersensitivity to the active substance(s) or to one of the excipients.
In very rare cases, systemic symptoms (such as lethargy), neurological symptoms (such as muscle tremors and ataxia) and/or gastrointestinal symptoms (such as vomiting, diarrhea, anorexia and salivation) may be observed after administration of the veterinary drug.
Specific warnings for each target species
Professional advice should be sought to establish an effective worm control program, taking into account the epidemiological context and the dog's living conditions.
Parasite resistance to a particular class of anthelmintic may develop following frequent and repeated use of an anthelmintic of that class.
Special precautions for use in animals: read the leaflet
What is its composition?
Milbemycin oxime ..... 12.5 mg
Praziquantel ..... 125.0 mg
Excipient QSP ..... 1 tablet of 625 mg
Packaging:
Box of 2 palatable tablets