Bad cholesterol is deposited in the bloodstream in the form offatty deposits. Eventually, cholesterol narrows blood vessels, preventing blood from circulating properly and partially obstructing tissues. A clot can then form, completely blocking an artery and causing serious health problems. Excess cholesterol is detrimental to health, and can lead in the long term to heart attacks , strokes and arteritis of the lower limbs.
Our cholesterol levels reflect our diet, which is often too rich in fats.
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After a meal, insulin secreted by the pancreas signals the body to lower circulating sugar levels. This mechanism maintains blood sugar levels at an appropriate level. When this mechanism is disrupted, the body's organs have difficulty in capturing and storing sugar as efficiently: this is known as insulin resistance. In its early stages, this phenomenon may go undetected, as the pancreas can produce larger quantities of insulin to compensate for this loss of efficiency, enabling the organs to continue to capture and store sufficient sugar.
While this compensatory hyperinsulinemia helps to maintain blood sugar levels at roughly normal levels, it causes various metabolic abnormalities (dyslipidemia, hepatic steatosis, hypertension) which can represent a major risk factor for cardiovascular disease. And when insulin overproduction persists, the pancreas becomes exhausted, stops producing insulin and type 2 diabetes appears, further increasing the risk of cardiovascular disease (heart attack and stroke) and damage to tissues whose function depends on small blood vessels, such as the retina, kidneys or nerves.
The good news is that this phenomenon is not irreversible, and can be resolved by a change in lifestyle. For example, the study published in 2018 in the journal Nutrients shows that adopting a diet consisting mainly of low-fat plant-based foods improves insulin sensitivity in overweight people. Physical activity is another avenue: the study of 44,828 Chinese adults aged between 20 and 80 with above-normal fasting blood sugar levels, published in 2018 in the British Journal of Sports Medicine, showed that those who were most physically active had a 25% lower risk of developing type 2 diabetes.
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