What are the characteristics of Griffonia?

The people of West Africa use this species both as a medicinal plant and as a food. The pulp of the bark is used as a poultice on wounds, while the leaves are applied to burns. The leaf decoction is used as a purgative, while the juice is said to treat kidney and bladder disorders, as well as eye inflammation. Root extract is used locally to treat sickle-cell anemia. The widely-used seed is reputed for its aphrodisiac properties, and is also used for diarrhea and gastralgia.

Botanical family: Fabaceae

Producer organ: Seeds

Known or presumed mode of action:

5-hydroxy-tryptophan (5-HTP) is the immediate precursor of serotonin, a key neurotransmitter involved in various biological processes. Because of its ability to induce all the biological effects associated with serotonin, the administration of a single dose of 5-HTP is frequently used as a challenge test tool to assess the functioning of the serotonergic system.

The neurons of the raphe nucleus, located in the brain stem, play a central role in serotonin biosynthesis. These neurons use plasma tryptophan as a starting substrate. A specific enzyme, tryptophan hydroxylase, catalyzes the conversion of tryptophan into 5-hydroxytryptophan (5-HTP). The latter is then converted into serotonin by another enzyme, L-amino acid decarboxylase.

This tightly regulated enzymatic process underlines the importance of 5-HTP as an essential intermediary in serotonin production, and illustrates its key role in maintaining the balance of serotonergic functions within the central nervous system.

What are the precautions for use?

Avoid use by pregnant or breast-feeding women

For adults only

Isolated 5-HTP may cause drowsiness

Prolonged treatment with 5-HTP may cause convulsions in people with Down's syndrome

Monitor effects of concomitant 5-HTP and St. John's Wort or SRIs (risk of increased serotonin levels resulting in serotonin syndrome)

Do not use in case of scleroderma

Do not use in case of carcinoid tumor (which produces serotonin)

Avoid association with carbidopa, as simultaneous use of carbidopa and 5-HTP significantly increases blood levels of 5-HTP and may induce a scleroderma-like disease with elevated kynurenine levels.

Contraindicated in epileptics

Risk of drug interactions with antidepressants, monoamine oxidase inhibitors (MAOIs) and serotonin reuptake inhibitors (SSRIs, SNRIs), analgesics(tramadol) and migraine medications(triptans).

Main plant components :

The plant is distinguished by its rich composition of bioactive compounds, the main ones being as follows:

5-HTP is a direct precursor of serotonin, widely recognized for its neuromodulatory properties and its involvement in the functioning of the serotonin system.

The plant contains a variety of bioactive alkaloids, including :

Hyrtioerectin B
3-carboxy-6-hydroxy-β-carboline
Hyrtiosulawesine
5-hydroxyindole-3-carbaldehyde
5-hydroxy-3-(2-hydroxyethyl) indole
Trigonelline
5-hydroxytryptamine
Griffonine

These alkaloids are associated with various biological effects, notably in the fields of neurological regulation and antioxidant activities.

Rhodamine-type lectins potentially contribute to specific biological interactions, notably in cell recognition and immunomodulation.

The seed of this plant is authorized as an ingredient in dietary supplements in France, in accordance with current regulations, due to its functional properties and established safety profile. This chemical profile highlights the plant's potential as a source of active ingredients for health and nutrition.

How to maintain nervous balance with griffonia extract?

Griffonia extract is a natural substance that is becoming increasingly popular for its effects on nervous balance. If you're looking to maintain your nervous balance with griffonia extract, here are a few tips to follow:

Understand the effects of griffonia extract on the body: Griffonia extract contains 5-HTP, a precursor of serotonin, which is a neurotransmitter important for regulating mood and anxiety.

Consult a healthcare professional: Before taking griffonia extract, it's important to consult a healthcare professional to discuss your specific needs and general health.

Follow dosage instructions: It is important to follow the dosage instructions on the package or those provided by your healthcare professional. Do not exceed the recommended dosage.

Take regularly: Griffonia extract must be taken regularly to feel its effects. We recommend taking griffonia extract on an empty stomach, preferably in the morning.

Combine with other stress management methods: To maximize the effects of griffonia extract, it is advisable to combine its use with other stress management methods such as meditation, yoga, physical exercise, a balanced diet and so on.

In short, griffonia extract can help maintain nervous balance, but it's important to consult a health professional and follow dosage instructions for maximum benefit. By combining its use with other stress management methods, you can help improve your overall well-being.

Which Stress and Sleep food supplements does Soin-et-Nature offer?

Soin-et-Nature offers a comprehensive range of food supplements to help manage stress and improve sleep quality. Here are the main categories available:

To promote emotional balance, specific supplements help maintain mental and emotional stability on a daily basis.

To improve sleep quality, natural solutions help you fall asleep quickly and get a good night's sleep.

To regulate sleep cycles, melatonin offers invaluable help in the fight against jet lag and insomnia.

To manage daily stress, natural supplements help relieve tension and restore a state of calm.

To cultivate serenity and well-being, balanced formulas provide overall support for body and mind.

To enjoy the benefits of Griffonia, this plant helps regulate mood and promote quality sleep thanks to its 5-HTP content.

A natural antidepressant, St. John's Wort is a gentle and effective alternative to combat low spirits.

To boost mental and physical energy in the face of stress, Rhodiola acts as a natural adaptogen to better withstand everyday challenges.

These dietary supplements available from Soin-et-Nature provide an effective response to stress and sleep-related needs, helping you to regain your natural balance and improve your quality of life.